Do not get drunk with wine, for that is debauchery; but be filled with the Spirit, as you sing psalms and hymns and spiritual songs among yourselves, singing and making melody to the Lord in your hearts, giving thanks to God the Father at all times and for everything in the name of our Lord Jesus Christ. – Ephesians 5:18-20

This verse speaks about the contrast of being intoxicated with wine in contrast to being filled with the Holy Spirit. Intoxication means being out of control. People in Ephesus would often associate intoxication with their pagan worship by drinking wine until they got out of control. The Apostle Paul tells them that this is not the Christian way of worship. Christians should be filled with the Holy Spirit, singing hymns and spiritual songs, making melody in your hearts, and giving thanks to God at all times. We Christians understand that intoxication is unacceptable according to the Bible. What about those Christians who are not drinking or have never tasted a drop of wine? Intoxication is defined as being driven out of control. So the principle here is that we should not be driven out of control by anything like our emotions, fear, anger, desires, or anything else that influences us. It’s the Holy Spirit that should guide us, teach us, and influence our lives to glorify God